Three patients died in the HSCT group and four patients died in the PBSCT group. Thirteen patients (11%) had major organ involvement. Outcome measures included hematological parameters, disease activity, autoantibodies, and the patient’s quality of life (QOL). Eighteen patients with moderate SLE had PSCST. Three patients received HSCT for secondary SLE. Twenty-four patients had hematopoietic stem cell transplantation (HSCT) and 19 patients had autologous peripheral blood stem cell transplantation (PBSCT). Seventy-one patients (46%) had active disease. We sought to assess the effectiveness of stem cell transplantation (SCT) for the treatment of severe SLE. Because anti-nuclear autoantibodies (ANAs) and circulating immune complexes are considered to be pathogenic factors in the disease, most of the treatment strategies of SLE aim at the prevention of autoantibody production. Systemic lupus erythematosus (SLE) is a prototypic systemic autoimmune disease in which both autoantibody production and immune dysregulation contribute to tissue damage. visit Old .Stem cell transplantation in systemic lupus erythematosus: results of the US-based NIEHS interdisciplinary Stem Cell Network for systemic lupus erythematosus (SCNSI) registry. The Rover UC metal detector is disguised as a walking stick and allows searching in areas where.
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